TXNIP Antibodies

Target Information

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). Belongs to the arrestin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

1200008J08Rik; AA682105; ARRDC6; EST01027; HHCPA78; Hyp; hyperlipidemia 1; Hyplip1; mVDU; OTTMUSP00000023522; OTTMUSP00000023523; Tbp-2; THI; THIF; thioredoxin binding protein 2; thioredoxin binding protein-2; thioredoxin interacting protein; Thioredoxin-binding protein 2; Thioredoxin-interacting protein; TXNIP; Txnip; upregulated by 1,25-dihydroxyvitamin D-3; VDU; VDUP1; Vdup1; Vitamin D3 up-regulated protein 1