CD81 (D5O2Q) Rabbit mAb (PE Conjugate) #93765
- F
Supporting Data
| REACTIVITY | M |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Rabbit IgG |
Application Key:
- F-Flow Cytometry
Species Cross-Reactivity Key:
- M-Mouse
Product Information
Product Description
Product Usage Information
| Application | Dilution |
|---|---|
| Flow Cytometry (Fixed/Permeabilized) | 1:50 |
Storage
Protocol
Specificity / Sensitivity
CD81 (D5O2Q) Rabbit mAb (PE Conjugate) recognizes endogenous levels of total CD81 protein.
Species Reactivity:
Mouse
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro184 of mouse CD81 protein.
Background
CD81 belongs to the tetraspanin family, which is characterized by four transmembrane domains, one short extracellular domain (ECL1), and one long extracellular domain (ECL2) (1-3). Tetraspanins interact with a variety of cell surface proteins and intracellular signaling molecules in specialized tetraspanin enriched microdomains (TEMs) where they mediate a range of processes including adhesion, motility, membrane organization, and signal transduction (3). CD81, like other tetraspanins, is enriched in exosomes (4). Many research studies demonstrate a role for CD81 in lymphocyte signaling (5-7). CD81 is also a well-characterized receptor for Hepatitis C Virus and facilitates the entry of the virus into target cells (8, 9).
- Oren, R. et al. (1990) Mol Cell Biol 10, 4007-15.
- Levy, S. et al. (1991) J Biol Chem 266, 14597-602.
- Hemler, M.E. (2005) Nat Rev Mol Cell Biol 6, 801-11.
- Escola, J.M. et al. (1998) J Biol Chem 273, 20121-7.
- Levy, S. et al. (1998) Annu Rev Immunol 16, 89-109.
- Levy, S. and Shoham, T. (2005) Nat Rev Immunol 5, 136-48.
- Jones, E.L. et al. (2011) Biochem Soc Trans 39, 506-11.
- Pileri, P. et al. (1998) Science 282, 938-41.
- Bartosch, B. et al. (2003) J Biol Chem 278, 41624-30.
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