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8472
Insulin (C27C9) Rabbit mAb (Pacific Blue™ Conjugate)

Insulin (C27C9) Rabbit mAb (Pacific Blue™ Conjugate) #8472

This product is discontinued

Storage:

Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.

Insulin (C27C9) Rabbit mAb (Pacific Blue™ Conjugate) detects endogenous levels of total insulin protein.

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence of human insulin.

This Cell Signaling Technology antibody is conjugated to Pacific Blue™ fluorescent dye and tested in-house for direct flow cytometry in human and mouse cells. The antibody is expected to exhibit the same species cross-reactivity as the unconjugated antibody Insulin (C27C9) Rabbit mAb #3014.

The maintenance of glucose homeostasis is an essential physiological process that is regulated by hormones. An elevation in blood glucose levels during feeding stimulates insulin release from pancreatic β cells through a glucose sensing pathway (1). Insulin is synthesized as a precursor molecule, proinsulin, which is processed prior to secretion. A- and B-peptides are joined together by a disulfide bond to form insulin, while the central portion of the precursor molecule is cleaved and released as the C-peptide. Insulin stimulates glucose uptake from blood into skeletal muscle and adipose tissue. Insulin deficiency leads to type 1 diabetes mellitus (2).

  1. Straub, S.G. and Sharp, G.W. (2002) Diabetes Metab. Res. Rev. 18, 451-463.
  2. Concannon, P. et al. (1998) Nat. Genet. 19, 292-296.
Entrez-Gene Id
3630
Swiss-Prot Acc.
P01308
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
Pacific Blue is a trademark of Molecular Probes, Inc.

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