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TREM1 (D7D6I) Rabbit Monoclonal Antibody (Flow Specific) #96768

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Inquiry Info. # 96768

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    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Rabbit IgG
    Application Key:
    • F-Flow Cytometry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Flow Cytometry (Live) 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    TREM1 (D7D6I) Rabbit Monoclonal Antibody (Flow Specific) recognizes endogenous levels of total TREM1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the extracellular domain of human TREM1 protein.

    Background

    Triggering receptor expressed on myeloid cells 1 (TREM1) is a cell surface receptor found on neutrophils, monocytes, and macrophages, where it plays a critical role in regulating immune responses (1). TREM1 is activated by various extracellular ligands, including PGLYRP1, HMGB1, and eCIRP (CIRBP) (2). Upon activation, TREM1 associates with and induces the phosphorylation of its adaptor protein, DAP12, triggering downstream signaling pathways that drive proinflammatory cytokine production (3).Acting as an inflammatory amplifier, TREM-1 contributes to the pathogenesis of infectious diseases (4), non-infectious tissue damage (5), autoimmune disorders (6), and sepsis (7). In the central nervous system, TREM-1 expression in microglia promotes activation and polarization toward a proinflammatory phenotype, thereby facilitating disease progression (8). In the liver, TREM-1 is expressed on non-parenchymal cells (NPCs), where it stimulates the release of cytokines and chemokines and regulates lipid metabolism and fibrosis (9). Furthermore, TREM-1 promotes cancer cell proliferation, migration, and invasion by modulating tumor-associated inflammation and the microenvironment (10, 11). Consequently, targeting TREM-1 represents a promising therapeutic strategy for these diverse inflammatory conditions.

    Alternate Names

    CD354; TREM-1; TREM1; Triggering receptor expressed on monocytes 1; Triggering receptor expressed on myeloid cells 1; triggering-receptor TREM1

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