Human FGF-21 Recombinant Protein #96551
Product Information
Storage
Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC.
Product Description
| MW (kDa) | 19.5 |
| Purity | A greater than or equal to 95% purity was determined by SDS-PAGE. |
| Endotoxin | Endotoxin levels are less than or equal to 1 EU / 1 μg hFGF-21. |
| Activity | The bioactivity of recombinant hFGF-21 was determined in an NIH-3T3 cell proliferation assay. The ED50 of each lot is less than or equal to 500 ng/mL. |
Source / Purification
Recombinant human FGF-21 was expressed in E. coli and is supplied in a lyophilized form.
Background
FGF-21 is a member of the large and diverse fibroblast growth factor (FGF) family of peptide growth factors. FGF-21 functions as a signaling molecule that is involved in many important processes (1,2). It binds to receptors FGFR1c and βKlotho (KLB) to drive protein interactions and formation of signaling complexes at the plasma membrane (3,4). FGF-21 functions as a regulator of glucose uptake in mice and primary human adipocytes (5). When overexpressed in transgenic mice, FGF-21 did not induce mitogenicity, hypoglycemia, or weight gain in diabetic or healthy animals (5).
Limited Uses
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