|Purity||A greater than or equal to 95% purity was determined by SDS-PAGE.|
|Endotoxin||Endotoxin levels are less than or equal to 1 EU / 1 μg hFGF-5.|
|Activity||The bioactivity of recombinant hFGF-5 was determined in an NR6R-3T3 cell proliferation assay. The ED50 of each lot is less than or equal to 10 ng/mL.|
Recombinant human FGF-5 was expressed in E. coli and is supplied in a lyophilized form.
FGF-5 is a member of the large and diverse fibroblast growth factor (FGF) family of peptide growth factors. FGF-5 binds to receptor FGFR1 and functions as a signaling molecule that plays a critical role in the regulation of the hair cycle (1,2). Mutations in FGF5 exhibit familial trichomegaly, a condition that involves a significant increase in the anagen phase of the hair growth cycle as well as extremely long eyelashes (1). FGF-5 also plays an important role in androgenetic alopecia as demonstrated in a genome-wide association study of men with early onset of this disease. Polymorphisms in FGF-5 have a strong association with the biology of male pattern hair loss (3). Clinical studies have shown that topical application of formulations containing FGF-5 are beneficial to men and women experiencing hair loss (4).
UniProt ID: P12034-2
Entrez-Gene Id: 2250
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