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Human IL-11 Recombinant Protein
Cytokines & Growth Factors
Growth Factors and Cytokines

Human IL-11 Recombinant Protein #57529

Citations (0)
Serial dilutions of Human IL-11 Recombinant Protein were added to TF-1 cells. Cell proliferation was measured and the linear portion of the curve was used to calculate the ED50.
The purity of Human IL-11 Recombinant Protein was determined by SDS-PAGE of 1 µg reduced (+) and non-reduced (-) recombinant hIL-11 and staining with Coomassie Blue.


Human IL-11 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg/ml which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage.

Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC.

Product Description

MW (kDa) 19.3
Purity A greater than or equal to 95% purity was determined by SDS-PAGE.
Endotoxin Endotoxin levels are less than or equal to 1 EU / 1 μg hIL-11.
Activity The bioactivity of recombinant hIL-11 was determined in a TF-1 cell proliferation assay. The ED50 of each lot is less than or equal to 10 ng/ml.

Source / Purification

Recombinant human IL-11 was expressed in E. coli and is supplied in a lyophilized form.


Interleukin-11 (IL-11) was initially cloned as a mediator of plasmacytoma cell proliferation and was later found to exhibit a wide variety of biological effects in neural cells as well as in the hematopoietic and immune systems (1). IL-11 belongs to the interleukin-6 (IL-6)-type subfamily of long-chain helical cytokines, including IL-6, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M, and cardiotrophin-1, which all share the glycoprotein gp130 as a signal transducing receptor component. IL-11 acts on cells expressing gp130 and the IL-11 receptor (IL-11R) α subunit. Both receptor subunits belong to the family of class I cytokine receptors. The complex of IL-11 and IL-11R triggers the activation of gp130 most likely by enforcing gp130 homodimerization (2). As a consequence of gp130 activation, several cytoplasmic signal transduction cascades are initiated from the Janus kinase (Jak)/signal transducer and activator of transcription (Stat) pathway, which has attracted considerable attention. Initiation of the Jak/Stat pathway in response to IL-11 requires Jak1 and leads predominantly to the activation of Stat3 (3,4).

Limited Uses

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For Research Use Only. Not for Use in Diagnostic Procedures.
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To Purchase # 57529
Cat. # Size Qty. Price
10 µg