|Purity||A greater than or equal to 95% purity was determined by SDS-PAGE.|
|Endotoxin||Endotoxin levels are less than or equal to 1 EU / 1 μg hWISP2.|
Recombinant human WISP2 was expressed in E. coli and is supplied in a lyophilized form.
WNT1 inducible signaling pathway protein 2 (WISP2 or CCN5) belongs to the CCN (Cyr61, Ctgf, NOV) family of proteins. It is a cysteine-rich secretory protein that associates with components of the extracellular matrix (1-3). WISP2 is expressed in endoderm, mesoderm, and ectoderm lineages, including primary osteoblasts, fibroblasts, ovaries, testes, and heart cells (3,4). This protein has been found to regulate cell proliferation, adhesion, signaling, wound healing, fibrosis, skeletal development, and metastasis (5). WISP2 promotes the adhesion of osteoblasts, inhibits osteocalcin production, and inhibits fibrinogen binding to integrin receptors (6). WISP2 is normally expressed in both embryonic and adult tissues (7,8).
UniProt ID: O76076
Entrez-Gene Id: 8839
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