Render Target: STATIC
Render Timestamp: 2024-10-11T10:52:33.415Z
Commit: 56767fe525c928647c8401233a175d0d607d385d
XML generation date: 2024-09-18 13:54:16.798
Product last modified at: 2024-10-01T13:45:09.353Z
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PDP - Template Name: InTraSeq Conjugate
PDP - Template ID: *******e148868

CD8α (SK1) Mouse mAb (InTraSeq 3' Conjugate 3030) #25292

Filter:
  • SCA

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Mouse IgG1
    Application Key:
    • SCA-Single Cell Analysis 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Storage

    Supplied in PBS (pH 7.2), 2 mM EDTA, 0.05% Triton X-100, 2 mg/mL BSA, and 50% glycerol. Store at -20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    CD8α (SK1) Mouse mAb (InTraSeq™ 3' Conjugate 3030) recognizes endogenous levels of total CD8α protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with human peripheral blood T cells.

    Background

    Cluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated α and β subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. On T cells, CD8 is the coreceptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the Ig-like domain of CD8α interacts with the α3-domain of the MHC class I molecule. CD8 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and the α chain recruits the tyrosine kinase Lck, which is essential for T cell activation (1).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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