Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
5-HTR1A Antibody recognizes transfected levels of total 5-HTR1A protein. Thus far, endogenous levels of 5-HTR1A have not been detected with this antibody.
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human 5-HTR1A protein. Antibodies are purified by protein A and peptide affinity chromatography.
Serotonin (5-hydroxytryptamine/5-HT) is a monoamine found in the central nervous system. Serotonin receptors are mostly members of the G Protein-Coupled Receptor (GPCR) superfamily. GPCRs are a family of cell surface receptors containing seven transmembrane proteins. GPCRs activate signal transduction pathways and cyclic AMP formation (1). Seven subclasses of serotonin receptors (5-HTR) have been described (5-HTR1-7). There are five subclasses of 5-HTR1 (1A, 1B, 1D, 1E, and 1F). 5-HTR1A is an inhibitory GPCR expressed both in serotonergic neurons and in target areas receiving serotonergic innervation. These receptors are associated with depression, anxiety, and the response to antidepressants (2).
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