Buy Three, Get the Fourth Free! | Start Saving >>
9879
5-HTR1A Antibody
Primary Antibodies

5-HTR1A Antibody #9879

This product is discontinued

Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

5-HTR1A Antibody recognizes transfected levels of total 5-HTR1A protein. Thus far, endogenous levels of 5-HTR1A have not been detected with this antibody.

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human 5-HTR1A protein. Antibodies are purified by protein A and peptide affinity chromatography.

Serotonin (5-hydroxytryptamine/5-HT) is a monoamine found in the central nervous system. Serotonin receptors are mostly members of the G Protein-Coupled Receptor (GPCR) superfamily. GPCRs are a family of cell surface receptors containing seven transmembrane proteins. GPCRs activate signal transduction pathways and cyclic AMP formation (1). Seven subclasses of serotonin receptors (5-HTR) have been described (5-HTR1-7). There are five subclasses of 5-HTR1 (1A, 1B, 1D, 1E, and 1F). 5-HTR1A is an inhibitory GPCR expressed both in serotonergic neurons and in target areas receiving serotonergic innervation. These receptors are associated with depression, anxiety, and the response to antidepressants (2).

  1. Mastrangelo, L. et al. (2008) Cancer Res 68, 5487-91.
  2. Fisher, P.M. et al. (2006) Nat Neurosci 9, 1362-3.
Entrez-Gene Id
3350
Swiss-Prot Acc.
P08908
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

Upstream / Downstream

pathwayImage

Explore pathways related to this product.