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80 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

DDX4 Antibody detects endogenous levels of total DDX4 protein.

Species predicted to react based on 100% sequence homology: Monkey

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly265 of human DDX4 protein. Antibodies are purified by protein A and peptide affinity chromatography.

DDX4 is an ATP-dependent DEAD-box RNA helicase found in the chromatoid body of the germ cells (1). This enzyme is specific to germ cells and is necessary for germ cell development (2). Mouse DDX4 was shown to interact with Dicer, suggesting a role in microRNA-mediated RNA silencing (1).

1.  Kotaja, N. et al. (2006) Proc Natl Acad Sci USA 103, 2647-52.

2.  Albamonte, M.S. et al. (2008) Hum Reprod 23, 1895-901.

Entrez-Gene Id 54514
Swiss-Prot Acc. Q9NQI0

For Research Use Only. Not For Use In Diagnostic Procedures.
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DDX4 Antibody