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52 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

NDP52 Antibody recognizes endogenous levels of total NDP52 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro372 of human NDP52 protein. Antibodies are purified by protein A and peptide affinity chromatography.

NDP52 (CALCOCO2) is ubiquitously expressed and composed of an amino-terminal SKICH domain, followed by a coiled-coil domain, and two zinc finger domains (1). It has recently been reported to act as an autophagy receptor that binds cytosolic ubiquitinated bacteria, leading to autophagy activation and pathogen clearance (1-3). NDP52 binds ubiquitin through its zinc finger domain and simultaneously binds LC3, which directs the bacteria into autophagosomes. In addition, NDP52 interacts with Nap1 and SINTBAD to recruit TBK1 to ubiquitinated bacteria (1).

1.  Thurston, T.L. et al. (2009) Nat Immunol 10, 1215-21.

2.  Cemma, M. et al. (2011) Autophagy 7, 341-5.

3.  Mostowy, S. et al. (2011) J Biol Chem 286, 26987-95.

Entrez-Gene Id 10241
Swiss-Prot Acc. Q13137

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

NDP52 Antibody