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3903
AFP (3H8) Mouse mAb

AFP (3H8) Mouse mAb #3903

This product is discontinued

We recommend the following alternatives

  • WB
  • IP
H
Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

AFP (3H8) Mouse mAb detects endogenous levels of total AFP protein.

Monoclonal antibody is produced by immunizing animals with a recombinant fragment of human AFP.

Alpha-fetoprotein (AFP) is a 65 kDa glycoprotein found in the mammalian fetal liver, yolk sac, and GI tract. While AFP expression in adult cells is low, it is aberrantly expressed in adult liver cancer cells (1,2). The tumor suppressor gene p53 and β-catenin are both involved in the regulation of AFP expression. In normal adult cells, p53 binds to the repressor region of the AFP gene, thereby blocking transcription. Mutations in both p53 and β-catenin are associated with aberrant expression of AFP. Research studies have shown that elevated serum AFP levels are predictive of hepatocellular carcinoma (3).

  1. Meier, V. et al. (2006) Comp Hepatol 5, 2.
  2. Warnes, T.W. and Smith, A. (1987) Baillieres Clin Gastroenterol 1, 63-89.
  3. Peng, S.Y. et al. (2004) Int J Cancer 112, 44-50.
Entrez-Gene Id
174
Swiss-Prot Acc.
P02771
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
DRAQ5 is a registered trademark of Biostatus Limited.

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