AKAP12 (F4H6G) Rabbit mAb #48427
- WB
- IF
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 300 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunofluorescence (Immunocytochemistry) | 1:800 - 1:1600 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
AKAP12 is highly expressed in heart, regulates desensitization and recycling of β2-adrenergic-receptor (β2AR), and has been implicated in cardiovascular disease initiation and progression (6). Increased expression of AKAP12 in heart is associated with accelerated cardiac dysfunction (7).
- Wu, X. et al. (2018) Biomed Environ Sci 31, 927-932.
- Li, H. (2022) Sci Prog 105, 368504221109212.
- Li, X. et al. (2023) Mol Cell Probes 72, 101939.
- Li, K. et al. (2023) Clin Transl Oncol 25, 3263-3276.
- Liang, Q. et al. (2022) Front Genet 13, 943006.
- Qasim, H. and McConnell, B.K. (2020) J Am Heart Assoc 9, e016615.
- Qasim, H. et al. (2024) Circ Res 134, 1006-1022.
Limited Uses
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