Render Target: STATIC
Render Timestamp:
3/25/2025, 6:58:46 AM EDT
3/25/2025, 10:58:46 AM UTC
Commit: 8d93f7ebe45006d66c127727d817fc3f57c4fe9a
XML generation date: 2025-03-11 22:02:15.300
Product last modified at: 2025-03-13T08:00:10.659Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
  1. Products /
  2. Primary Antibodies /
  3. APOC2 (F4Q3M) Rabbit mAb
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

APOC2 (F4Q3M) Rabbit mAb #20256

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 9
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    APOC2 (F4Q3M) Rabbit mAb recognizes endogenous levels of total APOC2 protein. This antibody detects a 45 kDa and a 65 kDa protein of unknown identity in some cell lines.


    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val93 of human APOC2 protein.

    Background

    Apolipoprotein C-II (APOC2) is a secreted cofactor that promotes triglyceride hydrolysis by lipoprotein lipase (LPL) (1). Several pathogenic APOC2 variants that lead to APOC2 deficiency and high triglyceride levels have been identified (2,3). There is also data suggesting that APOC2 is upregulated in various forms of cancer and may influence metabolic pathways of cancer cells (4). In acute myeloid leukemia, APOC2 was found to be highly expressed and to promote cancer cell proliferation by interacting with CD36 and upregulating signaling through Lyn and Erk (5). APOC2 was also found to be overexpressed in gastric cancer and to promote cancer cell invasion, migration, and proliferation by upregulation of PI3K, Akt, and mTOR signaling (6).

    Database Links

    UniProt ID: P02655


    Entrez-Gene Id: 344


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    For Research Use Only. Not For Use In Diagnostic Procedures.
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