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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

ATAD3A (F6S8N) Rabbit mAb #89844

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  • WB
  • IHC

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 71
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunohistochemistry (Paraffin) 1:20000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    ATAD3A (F6S8N) Rabbit mAb recognizes endogenous levels of total ATAD3A protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human ATAD3A protein.

    Background

    ATPase family AAA domain-containing protein 3 (ATAD3) is a mitochondrial AAA+ ATPase protein localized between the inner and outer mitochondrial membrane (1). ATAD3 interacts with several inner mitochondrial membrane proteins, and its role includes stabilizing mitochondrial DNA, regulating mitochondrial fission/fusion, and regulating cholesterol homeostasis (2,3). ATAD3 has three paralogs, ATAD3A, ATAD3B, and ATAD3C. ATAD3B acts as a negative regulator of ATAD3A (4). Numerous ATAD3A mutations have been identified in patients with neurological diseases and neurodegenerative diseases, such as Huntington’s disease and Alzheimer’s disease. These mutations are distributed throughout different protein domains, resulting in dysfunctional ATAD3A (3-5).
    For Research Use Only. Not for Use in Diagnostic Procedures.
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