Render Target: STATIC
Render Timestamp: 2024-11-01T10:49:04.768Z
Commit: 23cb9f61fe67e1e9093fd644a533c4ff516a6463
XML generation date: 2024-09-30 01:59:47.129
Product last modified at: 2024-10-09T11:45:15.548Z
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

ATF7IP (F8C9I) Rabbit mAb #28299

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H Mk
    SENSITIVITY Endogenous
    MW (kDa) 190, 220
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100

    Protocol

    Specificity / Sensitivity

    ATF7IP (F8C9I) Rabbit mAb recognizes endogenous levels of total ATF7IP protein.

    Species Reactivity:

    Human, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human ATF7IP protein.

    Background

    Activating transcription factor 7-interacting protein (ATF7IP), also known as MCAF1 or AM, is a repressive chromatin factor that binds to SETDB1, enhancing its ability to catalyze histone H3 lysine 9 trimethylation (1-3). ATF7IP has a SUMO binding domain, which interacts with sumoylated MBD1 to recruit the SETDB1/ATF7IP heterodimer to sites of heterochromatin (4). Loss of ATF7IP results in degradation of SETDB1 protein and a global loss of H3K9me3 (5). ATF7IP can localize to PML bodies in a SUMO-dependent manner, causing reduced histone mRNA and protein and cellular senescence (6). ATF7IP has also been implicated in cancer, where it interacts with SP1 to regulate telomerase. It can also contribute to immune cell function by inhibiting the IL-2 and IL-7R genes (7-9).
    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.