β-Hydroxybutyryl Lysine (E6H5Q) Rabbit mAb #95132
- WB
Supporting Data
| REACTIVITY | All |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- All-All Species Expected
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Notable bhb-modified substrates identified through proteomic investigations include histones, as well as non-histone substrates such as FASN and TP53 (4-6). In models where cells are incubated with excess β-hydroxybutyrate to induce this PTM, protein sites displaying upregulated bhb levels differ from sites displaying upregulated acetylation levels, suggesting potential differences in Kbhb-induced pathways and crosstalk between distinct modification types.
- Huang, H. et al. (2021) Sci Adv 7, eabe2771. doi: 10.1126/sciadv.abe2771.
- Wei, S. et al. (2022) Front Mol Biosci 9, 823602.
- Zeaiter, N. et al. (2024) Mol Metab 81, 101903.
- Xie, Z. et al. (2016) Mol Cell 62, 194-206.
- Hou, W. et al. (2022) Oxid Med Cell Longev 2022, 4592170.
- Liu, K. et al. (2019) Cell Death Dis 10, 243.
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