C-Peptide (E9C4P) Rabbit mAb #51634

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Supporting Data

REACTIVITY	M R
SENSITIVITY	Endogenous
MW (kDa)	4
Source/Isotype	Rabbit IgG

Application Key:

IHC-Immunohistochemistry
IF-Immunofluorescence

Species Cross-Reactivity Key:

M-Mouse
R-Rat

Product Information

Product Usage Information

Application	Dilution
Immunohistochemistry (Paraffin)	1:500 - 1:2000
Immunofluorescence (Frozen)	1:100 - 1:400

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

C-Peptide (E9C4P) Rabbit mAb recognizes endogenous levels of total C-peptide protein.

Species Reactivity:

Mouse, Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence of human C-peptide protein.

Background

Glucose homeostasis is regulated by hormones. Elevation of blood glucose levels during feeding stimulates insulin release from pancreatic β-cells through a glucose sensing pathway (1). Proinsulin, the insulin precursor molecule, is processed prior to its secretion. Insulin is composed of A-peptide and B-peptide which are joined by a disulfide bond. The center one-third of the molecule is cleaved and released as C-peptide, which has a longer half-life than insulin (2).

Database Links

UniProt ID: P01308

Entrez-Gene Id: 3630

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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