Render Target: STATIC
Render Timestamp: 2024-12-13T12:01:27.233Z
Commit: 611277b6de3cd1bb065350b6ef8d63df412b7185
XML generation date: 2024-08-30 10:37:19.597
Product last modified at: 2024-08-31T07:01:49.241Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

C1QB (E3U6X) Rabbit mAb (BSA and Azide Free) #43159

Filter:
  • WB
  • IHC

    Supporting Data

    REACTIVITY M
    SENSITIVITY Endogenous
    MW (kDa) 30
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • M-Mouse 

    Product Information

    Product Usage Information

    This product is the carrier free version of product #30651. All data were generated using the same antibody clone in the standard formulation which contains BSA and glycerol.

    This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.

    BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.

    Formulation

    Supplied in 1X PBS (10 mM Na2HPO4, 3 mM KCl, 2 mM KH2PO4, and 140 mM NaCl (pH 7.8)). BSA and Azide Free.

    For standard formulation of this product see product #30651

    Storage

    Store at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.

    Specificity / Sensitivity

    C1QB (E3U6X) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total C1QB protein.

    Species Reactivity:

    Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse C1QB protein.

    Background

    C1q is a key subcomponent of the classical complement activation pathway during the innate immune response, and it provides a link to the adaptive immune response (1), as the best-known ligands for C1q are the Fc regions of aggregated IgG and IgM molecules in immune complexes (2). Functional C1q is a complex heterotrimer consisting of the products of three genes: C1QA, C1QB, and C1QC (2). C1q is involved in autoimmunity, infection, inflammatory diseases, and tumors (3). C1q is constitutively synthesized by monocytes, macrophages, dendritic cells (DCs), and microglia, and decreased C1q levels are present in several autoimmune conditions (3,4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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