Render Target: STATIC
Render Timestamp: 2024-11-08T11:04:32.107Z
Commit: 3c1f305a63297e594ac8d7bb5424007d592d68be
XML generation date: 2024-09-30 01:59:24.529
Product last modified at: 2024-10-24T15:45:09.770Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

C1QB (E3U6X) Rabbit mAb #30651

Filter:
  • WB
  • IP
  • IHC

    Supporting Data

    REACTIVITY M
    SENSITIVITY Endogenous
    MW (kDa) 30
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:200
    IHC Leica Bond 1:400 - 1:1600
    Immunohistochemistry (Paraffin) 1:200 - 1:800

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    For a carrier free (BSA and azide free) version of this product see product #43159.

    Protocol

    Specificity / Sensitivity

    C1QB (E3U6X) Rabbit mAb recognizes endogenous levels of total C1QB protein.

    Species Reactivity:

    Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse C1QB protein.

    Background

    C1q is a key subcomponent of the classical complement activation pathway during the innate immune response, and it provides a link to the adaptive immune response (1), as the best-known ligands for C1q are the Fc regions of aggregated IgG and IgM molecules in immune complexes (2). Functional C1q is a complex heterotrimer consisting of the products of three genes: C1QA, C1QB, and C1QC (2). C1q is involved in autoimmunity, infection, inflammatory diseases, and tumors (3). C1q is constitutively synthesized by monocytes, macrophages, dendritic cells (DCs), and microglia, and decreased C1q levels are present in several autoimmune conditions (3,4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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