C1QB (E3U6X) Rabbit mAb #30651
- WB
- IP
- IHC
Supporting Data
| REACTIVITY | M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 30 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:200 |
| IHC Leica Bond | 1:400 - 1:1600 |
| Immunohistochemistry (Paraffin) | 1:200 - 1:800 |
Storage
For a carrier free (BSA and azide free) version of this product see product #43159.
Protocol
Specificity / Sensitivity
C1QB (E3U6X) Rabbit mAb recognizes endogenous levels of total C1QB protein.
Species Reactivity:
Mouse
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse C1QB protein.
Background
C1q is a key subcomponent of the classical complement activation pathway during the innate immune response, and it provides a link to the adaptive immune response (1), as the best-known ligands for C1q are the Fc regions of aggregated IgG and IgM molecules in immune complexes (2). Functional C1q is a complex heterotrimer consisting of the products of three genes: C1QA, C1QB, and C1QC (2). C1q is involved in autoimmunity, infection, inflammatory diseases, and tumors (3). C1q is constitutively synthesized by monocytes, macrophages, dendritic cells (DCs), and microglia, and decreased C1q levels are present in several autoimmune conditions (3,4).
Limited Uses
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