CA12 (D78E4) Rabbit mAb #5865
- WB
- IP
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 45-50 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:200 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
CA12, a member of the α class, is a plasma membrane protein with the catalytic domain in the extracellular space. CA12 is widely expressed in many tissues and is found at high levels in renal cell cancers. Its expression is induced by hypoxia in solid tumors and is considered to be a tumor marker (3-5). Genetic mutations in CA12 are associated with hyperchlorhidrosis (6, 7).
- Smith, K.S. et al. (1999) Proc Natl Acad Sci USA 96, 15184-9.
- Tripp, B.C. et al. (2001) J Biol Chem 276, 48615-8.
- Chiche, J. et al. (2009) Cancer Res 69, 358-68.
- Barnett, D.H. et al. (2008) Cancer Res 68, 3505-15.
- Watson, P.H. et al. (2003) Br J Cancer 88, 1065-70.
- Feldshtein, M. et al. (2010) Am J Hum Genet 87, 713-20.
- Muhammad, E. et al. (2011) Hum Genet 129, 397-405.
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