Cadherin-17 (E5J8Z) Rabbit mAb #85724
- WB
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 120 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunohistochemistry (Paraffin) | 1:250 - 1:1000 |
Storage
For a carrier free (BSA and azide free) version of this product see product #53536.
Protocol
Specificity / Sensitivity
Cadherin-17 (E5J8Z) Rabbit mAb recognizes endogenous levels of total cadherin-17 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human cadherin-17 protein.
Background
Cadherin-17/Liver-Intestine-cadherin (CDH17/LI-cadherin) is a type-I transmembrane glycoprotein that belongs to the 7D-cadherin superfamily. Unlike classical cadherins, CDH17 is characterized by an extracellular domain with seven cadherin repeats and a short intracellular domain (1). CDH17 is a calcium-dependent homotypic cell-cell adhesion molecule that, under normal physiologic conditions in humans, is selectively expressed on the basolateral surface of epithelia lining the small intestine and colon (2). Research studies have demonstrated that CDH17 is aberrantly overexpressed in human gastric cancer and may serve as a novel oncogenic biomarker for this disease (3,4). At the molecular level, research studies have suggested that CDH17 exerts its oncogenicity in the context of gastric cancer through its ability to engage both NF-κB and MAPK signaling cascades (5,6).
Limited Uses
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