CAPZA1 (E3U1G) Rabbit mAb #62114
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 33 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
CAPZA1 (E3U1G) Rabbit mAb recognizes endogenous levels of total CAPZA1 protein. This antibody does not cross-react with CAPZA2 protein. Based on the sequence of the peptide antigen, this antibody is not expected to cross-react with CAPZA3 protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg86 of human CAPZA1 protein.
Background
The F-actin-capping protein, a ubiquitously expressed heterodimer composed of structurally similar α and β subunits, regulates cytoskeletal organization and function by binding to the actin filament barbed ends and maintaining the cellular pool of monomeric actin (1).
F-actin-capping protein subunit α-1 (CAPZA1) overexpression is linked to more favorable prognosis in gastric cancer (2). In hepatocellular carcinoma, CAPZA1 inhibits epithelial-mesenchymal transition (EMT), migration, and invasion (3,4).
Limited Uses
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