Render Target: STATIC
Render Timestamp: 2024-10-04T11:04:19.041Z
Commit: f04ddd7fea9fb3592f59f61482fcb94610d25cbe
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

Cathepsin H (E6L4W) Rabbit mAb #54007

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 25
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Cathepsin H (E6L4W) Rabbit mAb recognizes endogenous levels of mature cathepsin H protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly309 of mouse cathepsin H protein.

    Background

    Cathepsin H (CTSH) is a broadly expressed lysosomal cysteine protease involved in the normal degradation of proteins. CTSH is synthesized as an inactive proenzyme that contains a prodomain and a mature domain, whereupon prodomain removal, the enzyme becomes active (1). High expression of CTSH is found in several cancer types, including thyroid carcinoma (2). CTSH can also process specific proteins, like the cytoskeletal protein talin, to regulate cellular processes, such as the abnormal migration of prostate cancer cells (3). The human gene encoding CSTH is also genetically linked to Alzheimer’s disease (4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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