Render Target: STATIC
Render Timestamp: 2025-01-22T13:35:43.105Z
Commit: da7e4f2f0d1aed1f1f8e20e4e2ecab8f33cbd595
XML generation date: 2024-12-24 23:02:06.920
Product last modified at: 2025-01-01T09:06:40.392Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

Cathepsin Z (F6D7U) Rabbit mAb #23368

Filter:
  • WB
  • IHC

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 33
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunohistochemistry (Paraffin) 1:500 - 1:2000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Cathepsin Z (F6D7U) Rabbit mAb recognizes endogenous levels of total cathepsin Z protein. Non-specific staining was observed in human salivary gland and in cardiomyocytes by immunohistochemistry.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn75 of human cathepsin Z protein.

    Background

    Cathepsin Z, also known as cathepsin X or cathepsin P, is a lysosomal cysteine proteinase member of the papain family encoded by the CTSZ gene (1,2). It contains a uniquely short pro-domain containing an RGD integrin binding sequence, allowing functionality in cell adhesion, signaling, and extracellular matrix remodeling (3,4). Cathepsin Z is expressed in immune cells, specifically macrophages, monocytes, and dendritic cells, where it participates in several immune cell functions (5). It may play a role in tumorigenesis and has been implicated in several cancer types, including hepatocellular carcinoma, glioblastoma, non-small cell lung cancer, prostate cancer, and colorectal cancer (6-10). Cathepsin Z is also expressed and secreted by activated microglia in the brain and may play a role in neuroinflammation (11,12).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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