Render Target: STATIC
Render Timestamp: 2024-10-11T10:01:38.240Z
Commit: 56767fe525c928647c8401233a175d0d607d385d
XML generation date: 2024-09-30 20:01:08.077
Product last modified at: 2024-10-02T14:15:17.250Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77

CD31 (PECAM-1) (158-2B3) Mouse mAb (BSA and Azide Free) #89852

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 130
    Source/Isotype Mouse IgG1
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.

    BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.

    Formulation

    Supplied in 1X PBS (10 mM Na2HPO4, 3 mM KCl, 2 mM KH2PO4, and 140 mM NaCl (pH 7.8)). BSA and Azide Free.

    Storage

    Store at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.

    Specificity / Sensitivity

    CD31 (PECAM-1) (158-2B3) Mouse mAb (BSA and Azide Free) detects endogenous levels of CD31.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing mice with stimulated human leucocytes.

    Background

    CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells, and endothelial cells and modulates cell adhesion, endothelial cell migration, and angiogenesis (1). CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical or oxidative stress), presumably by Src family members (2). The tyrosine phosphorylation mediates associations with a number of SH2 domain-containing binding partners such as PI3 kinase, SHIP, PLCγ, and SHP-2. Thus, CD31 serves as a scaffold for various signaling molecules (3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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