CD7 (LP15) Mouse mAb #94135
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Mouse IgG2b |
Application Key:
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| IHC Leica Bond | 1:100 - 1:400 |
| Immunohistochemistry (Paraffin) | 1:50 - 1:200 |
Storage
Protocol
Specificity / Sensitivity
CD7 (LP15) Mouse mAb recognizes endogenous levels of CD7 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a prokaryotic recombinant fusion protein corresponding to a portion of the extracellular domain of human CD7 protein.
Background
CD7 is a type-I transmembrane glycoprotein belonging to the immunoglobulin superfamily. CD7 is one of the earliest surface markers to be expressed on the surface of developing T cells and its expression is maintained throughout maturation of multiple T cell subsets and NK cells (1-3). Engagement of CD7 through binding its ligand, SECTM1, has been shown to promote tyrosine phosphorylation of its cytoplasmic domain, recruitment of PI3K, and delivery of costimulatory signals for T cell activation (4-6). While CD7 is expressed on normal T cells, it is also highly expressed in a variety of T cell malignancies, which has poised it as a potential target of immunotherapy (7-9).
- Haynes, B.F. et al. (1988) J Exp Med 168, 1061-80.
- Lobach, D.F. et al. (1985) J Immunol 135, 1752-9.
- Rabinowich, H. et al. (1994) J Immunol 152, 517-26.
- Ward, S.G. et al. (1995) Eur J Immunol 25, 502-7.
- Chan, A.S. et al. (1997) J Immunol 159, 934-42.
- Lyman, S.D. et al. (2000) J Biol Chem 275, 3431-7.
- Cooper, M.L. et al. (2018) Leukemia 32, 1970-1983. doi: 10.1038/s41375-018-0065-5.
- Png, Y.T. et al. (2017) Blood Adv 1, 2348-2360.
- Gomes-Silva, D. et al. (2017) Blood 130, 285-296.
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