CD70 (E3Q1A) Rabbit mAb (BSA and Azide Free) #35969
- WB
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 27, 54, 81 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN, or CUT&Tag assays. If you require a carrier-free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.
Formulation
For standard formulation of this product see product #69209.
Storage
Specificity / Sensitivity
CD70 (E3Q1A) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total CD70 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human CD70 protein.
Background
CD70 is a type II transmembrane glycoprotein and a member of the tumor necrosis factor ligand superfamily (TNFSF), also known as CD27L and TNFSF7. It is normally expressed on medullary thymic epithelial cells. Its expression is induced on activated lymphoid cells (B cells, T cells, and NK cells) and dendritic cells. CD70 is a ligand for CD27, a co-stimulatory receptor that plays an important role in T cell activation and proliferation (1,2). CD70 overexpression has been reported in various tumors such as renal cell carcinoma, glioblastoma, and non-small cell lung carcinoma and it’s being actively pursued as a therapeutic target (3-6).
- Borst, J. et al. (2005) Curr Opin Immunol 17, 275-81.
- Nolte, M.A. et al. (2009) Immunol Rev 229, 216-31.
- Wischhusen, J. et al. (2002) Cancer Res 62, 2592-9.
- Junker, K. et al. (2005) J Urol 173, 2150-3.
- Jacobs, J. et al. (2015) Oncotarget 6, 13462-75.
- van de Ven, K. and Borst, J. (2015) Immunotherapy 7, 655-67.
Limited Uses
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