|70306||CD8α (C8/144B) Mouse mAb (IHC Specific)||
|85336||CD8α (D8A8Y) Rabbit mAb||
|98941||CD8α (D4W2Z) XP® Rabbit mAb (Mouse Specific)||
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
CD8α (53-6.7) Rat mAb recognizes endogenous levels of mouse CD8α protein by flow cytometry.
Monoclonal antibody is produced by immunizing animals with mouse spleen cells.
Cluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated α and β subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. On T cells, CD8 is the coreceptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the Ig-like domain of CD8α interacts with the α3-domain of the MHC class I molecule. CD8 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and the α chain recruits the tyrosine kinase Lck, which is essential for T cell activation (1).
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