Claudin-11 (F5C7W) Rabbit mAb #80889
- WB
- IP
- IF
Supporting Data
| REACTIVITY | M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 21 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
| Immunofluorescence (Frozen) | 1:100 - 1:200 |
| Immunofluorescence (Immunocytochemistry) | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Claudin-11, originally identified as oligodendrocyte specific protein (OSP), is a transmembrane protein member of the claudin family, abundantly expressed by oligodendrocytes and within tight junctions of central nervous system myelin (7,8). Claudin-11 has been shown to form a complex with OSP-associated protein-1 (OAP-1) and beta-1 integrin, which may be involved in regulation of oligodendrocyte proliferation (9,10). Mouse models lacking claudin-11 fail to assemble these tight junctions, leading to altered neurotransmitter levels and significant loss of function behavioral changes (11).
- Shin, K. et al. (2006) Annu Rev Cell Dev Biol 22, 207-35.
- Oliveira, S.S. and Morgado-Díaz, J.A. (2007) Cell Mol Life Sci 64, 17-28.
- Hewitt, K.J. et al. (2006) BMC Cancer 6, 186.
- Brandner, J.M. et al. (2002) Eur J Cell Biol 81, 253-63.
- Krämer, F. et al. (2000) Hum Genet 107, 249-56.
- Swisshelm, K. et al. (1999) Gene 226, 285-95.
- Bronstein, J.M. et al. (1996) Neurology 47, 772-8.
- Morita, K. et al. (1999) J Cell Biol 145, 579-88.
- Tiwari-Woodruff, S.K. et al. (2001) J Cell Biol 153, 295-305.
- Gjervan, S.C. et al. (2023) Front Cell Neurosci 17, 1344090.
- Maheras, K.J. et al. (2018) Sci Rep 8, 3798.
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