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Primary Antibodies /
CMTM6 Antibody

CMTM6 Antibody #55829

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Supporting Data

REACTIVITY	M
SENSITIVITY	Endogenous
MW (kDa)	22
SOURCE	Rabbit

Application Key:

WB-Western Blotting
IP-Immunoprecipitation

Species Cross-Reactivity Key:

M-Mouse

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:50

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

CMTM6 Antibody recognizes endogenous levels of total mouse CMTM6 protein. This antibody cross-reacts with an unidentified protein of 35 kDa, 55 kDa, and 75 kDa in some cell extracts.

Species Reactivity:

Mouse

Source / Purification

Polyclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala176 of mouse CMTM6 protein. Antibodies are purified by peptide affinity chromatography.

Background

CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6) is a member of the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (1). CMTM6 stabilizes plasma membrane expression of PD-L1, an immune inhibitory ligand critical for immune tolerance to self and anti-tumor immunity (2,3). CMTM6 associates with PD-L1 at recycling endosomes, where it protects PD-L1 from being targeted for lysosomal degradation by preventing STUB1-mediated PD-L1 ubiquitination (2,3). CMTM6 may stabilize PD-L1 expression on antigen presenting cells and potentiate inhibitory signaling by PD-1 on T cells, triggering T cell inhibition and exhaustion. CMTM6 has also been shown to interact with CD58, ARG1, ENO1, and TMPO (2). Due to the role of CMTM6 in regulating the immune system, it is being investigated as an immunotherapeutic target for the treatment of cancer.

Database Links

UniProt ID: Q9CZ69

Entrez-Gene Id: 67213

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For Research Use Only. Not For Use In Diagnostic Procedures.

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