COL14A1 (E5W8S) Rabbit mAb #61964
- WB
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 220 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunohistochemistry (Paraffin) | 1:50 - 1:200 |
Storage
Protocol
Specificity / Sensitivity
COL14A1 (E5W8S) Rabbit mAb recognizes endogenous levels of total COL14A1 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human COL14A1 protein.
Background
COL14A1 (Collagen Type XIV, Undulin) is an interstitial collagen that belongs to the fibril-associated collagens with interrupted triple helices (FACIT) family (1). COL14A1 contributes to the assembly and remodeling of the interstitial extracellular matrix, in part by promoting the formation of inter-molecular bridges between collagen molecules (2-4). Changes in COL14A1 expression have been identified as a potential biomarker in a variety of fibrotic diseases, including idiopathic pulmonary fibrosis (5,6) and fibrotic kidney diseases (7). A study of tumor stroma-associated biomarkers furthermore revealed that COL14A1 was one of a group of genes whose expression correlated negatively with clinical stage of breast cancer patient samples (8).
- Dublet, B. and van der Rest, M. (1991) J Biol Chem 266, 6853-8.
- Brown, J.C. et al. (1993) J Cell Biol 120, 557-67.
- Shaw, L.M. and Olsen, B.R. (1991) Trends Biochem Sci 16, 191-4.
- Onursal, C. et al. (2021) Front Med (Lausanne) 8, 593874.
- Wan, H. et al. (2021) Front Mol Biosci 8, 711239.
- Tzortzaki, E.G. et al. (2003) Anat Rec A Discov Mol Cell Evol Biol 275, 1073-80.
- Marder, K. et al. (1995) Clin Nephrol 44, 178-84.
- Uddin, M.N. and Wang, X. (2022) Breast Cancer, doi: 10.1007/s12282-022-01332-6.
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