Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CPEB1 Antibody recognizes endogenous levels of total CPEB1 protein.
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu170 of human CPEB1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Cytoplasmic polyadenylation element-binding protein (CPEB) is a conserved protein that binds RNA and regulates translation (1-3). CPEB binds to the cytoplasmic polyadenylation element (CPE) located in the 3′ untranslated region (UTR) of specific mRNAs expressed in germ cells, fibroblasts, and neurons (1-4). Together with other factors, CPEB promotes polyadenylation of mRNA transcripts to create mRNA poly(A) tails prior to translation (1-3). CPEB1 regulates meiotic and early-embryonic cell proliferation and is essential for mediation of poly(A) tail length changes required for mitotic cell division (4). Research studies suggest that CPEB1-mediated shortening of the 3'-UTR correlates with tumorigenesis (5).
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