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13583
CPEB1 Antibody
Primary Antibodies

CPEB1 Antibody #13583

Reviews ()
Citations (2)

Supporting Data

REACTIVITY
SENSITIVITY
MW (kDa) 65
SOURCE Rabbit

Application Key:

  • W-Western
  • IP-Immunoprecipitation
  • IHC-Immunohistochemistry
  • ChIP-Chromatin Immunoprecipitation
  • IF-Immunofluorescence
  • F-Flow Cytometry
  • E-P-ELISA-Peptide

Species Cross-Reactivity Key:

  • H-Human
  • M-Mouse
  • R-Rat
  • Hm-Hamster
  • Mk-Monkey
  • Mi-Mink
  • C-Chicken
  • Dm-D. melanogaster
  • X-Xenopus
  • Z-Zebrafish
  • B-Bovine
  • Dg-Dog
  • Pg-Pig
  • Sc-S. cerevisiae
  • Ce-C. elegans
  • Hr-Horse
  • All-All Species Expected

Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

CPEB1 Antibody recognizes endogenous levels of total CPEB1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu170 of human CPEB1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Cytoplasmic polyadenylation element-binding protein (CPEB) is a conserved protein that binds RNA and regulates translation (1-3). CPEB binds to the cytoplasmic polyadenylation element (CPE) located in the 3′ untranslated region (UTR) of specific mRNAs expressed in germ cells, fibroblasts, and neurons (1-4). Together with other factors, CPEB promotes polyadenylation of mRNA transcripts to create mRNA poly(A) tails prior to translation (1-3). CPEB1 regulates meiotic and early-embryonic cell proliferation and is essential for mediation of poly(A) tail length changes required for mitotic cell division (4). Research studies suggest that CPEB1-mediated shortening of the 3'-UTR correlates with tumorigenesis (5).

  1. Hake, L.E. and Richter, J.D. (1994) Cell 79, 617-27.
  2. Mendez, R. et al. (2002) EMBO J 21, 1833-44.
  3. Kim, J.H. and Richter, J.D. (2006) Mol Cell 24, 173-83.
  4. Novoa, I. et al. (2010) Nat Cell Biol 12, 447-56.
  5. Bava, F.A. et al. (2013) Nature 495, 121-5.

Pathways & Proteins

Explore pathways + proteins related to this product.

For Research Use Only. Not For Use In Diagnostic Procedures.

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