CRELD1 (E1B6T) Rabbit mAb #87416
- WB
- IP
- F
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 45 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
- F-Flow Cytometry
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
| Flow Cytometry (Live) | 1:50 - 1:200 |
Storage
Protocol
Specificity / Sensitivity
CRELD1 (E1B6T) Rabbit mAb recognizes endogenous levels of total CRELD1 protein. Species reactivity for flow cytometry is human only.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CRELD1 protein.
Background
CRELD1 (Cysteine-rich with EGF-like domain protein 1, Cirrin) is a multi-pass membrane protein in the CRELD family of ER-resident proteins (1-3). During embryonic development, CRELD1 is critical to heart development, and mutations in CRELD1 are associated with Atrioventricular septal defect 2 (AVSD2), a common cardiovascular malformation (2-4). CRELD1 may also play a role in homeostasis of the immune system, as low CRELD1 expression was found to be associated with reduced T cell numbers in blood (5).
Limited Uses
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