Render Target: STATIC
Render Timestamp: 2024-12-10T10:56:38.000Z
Commit: 611277b6de3cd1bb065350b6ef8d63df412b7185
XML generation date: 2024-09-30 01:57:59.463
Product last modified at: 2024-09-30T08:00:34.793Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

CTHRC1 (E6W2E) Rabbit mAb #78524

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 29
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    CTHRC1 (E6W2E) Rabbit mAb recognizes endogenous levels of total CTHRC1 protein.

    Species Reactivity:

    Human

    The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.

    Species predicted to react based on 100% sequence homology:

    Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala226 of human CTHRC1 protein.

    Background

    Collagen triple helix repeat containing-1 (CTHRC1) is a secreted glycoprotein involved in wound repair, vascular and bone remodeling, matrix deposition, and migration. CTHRC1 is overexpressed in multiple human cancers, and its expression is associated with increased migration and metastasis, as well as decreased survival (1-3).
    CTHRC1 expression is regulated through TGF-β/Smad3 signaling, and its effects on migration and invasion are mediated by several signaling pathways, including TGF-β, Wnt, integrin β/FAK, Src/FAK, MEK/ERK, PI3K/AKT/ERK, HIF-1α, and PKC-δ/ERK (3). CTHRC1 protein is elevated in the peripheral blood of Rheumatoid arthritis (RA) patients, and CTHRC1 is thought to be a driver of RA progression (4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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