CTHRC1 (E6W2E) Rabbit mAb #78524
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 29 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
CTHRC1 (E6W2E) Rabbit mAb recognizes endogenous levels of total CTHRC1 protein.
Species Reactivity:
Human
The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.
Species predicted to react based on 100% sequence homology:
Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala226 of human CTHRC1 protein.
Background
Collagen triple helix repeat containing-1 (CTHRC1) is a secreted glycoprotein involved in wound repair, vascular and bone remodeling, matrix deposition, and migration. CTHRC1 is overexpressed in multiple human cancers, and its expression is associated with increased migration and metastasis, as well as decreased survival (1-3).
CTHRC1 expression is regulated through TGF-β/Smad3 signaling, and its effects on migration and invasion are mediated by several signaling pathways, including TGF-β, Wnt, integrin β/FAK, Src/FAK, MEK/ERK, PI3K/AKT/ERK, HIF-1α, and PKC-δ/ERK (3). CTHRC1 protein is elevated in the peripheral blood of Rheumatoid arthritis (RA) patients, and CTHRC1 is thought to be a driver of RA progression (4).
Limited Uses
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