Cystathionine γ-Lyase (D1N1D) Rabbit mAb #19689
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 44 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Cystathionine γ-Lyase (D1N1D) Rabbit mAb recognizes endogenous levels of total cystathionine γ-lyase protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro298 of human cystathionine γ-lyase protein.
Background
Cystathionine γ-lyase (CGL) is an enzyme in the transsulfuration pathway, a route in the metabolism of sulfur-containing amino acids (1). This enzyme regulates local vasodilation and blood pressure by generating hydrogen sulfide (H2S) as a physiological signaling molecule (2). A rodent model of sleep apnea showed that H2S production by cystathionine γ-lyase in the carotid body triggers hypertension in rodents during intermittent hypoxia, suggesting that inhibition of this enzyme may prevent the hypertension associated with sleep apnea (3). In addition, dietary restriction of sulfur-containing amino acids upregulates hepatic cystathionine γ-lyase expression in mice, leading to elevated production of H2S and protection from hepatic ischemia perfusion injury, indicating that this enzyme is critical for the benefits of dietary restriction (4).
Limited Uses
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