DcR2 Antibody #4741
- WB
Inquiry Info. # 4741
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Product Specifications
| REACTIVITY | H |
| SENSITIVITY | Transfected Only |
| MW (kDa) | 52 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Death receptor signaling can be controlled by a family of decoy receptors (DcR1, DcR2 and DcR3) that lack a cytoplasmic DD and inhibit death receptor-mediated apoptosis by competing for ligand binding (3-5). Expression of decoy receptors can contribute to chemosensitivity and may provide a mechanism for regulation of apoptosis in certain types of cancer (6-8).
- Nagata, S. (1997) Cell 88, 355-65.
- Thorburn, A. (2004) Cell Signal 16, 139-44.
- Sheridan, J.P. et al. (1997) Science 277, 818-821.
- Marsters, S.A. et al. (1997) Curr. Biol. 7, 1003-1006.
- Pitti, R.M. et al. (1998) Nature 396, 699-703.
- Liu, X. et al. (2005) Cancer Res. 65, 9169-9175.
- Spalding, A.C. et al. (2002) Oncogene 21, 260-271.
- Bernard, D. et al. (2001) J. Biol. Chem. 276, 27322-2738.
Alternate Names
CD264; DCR2; Decoy receptor 2; decoy with truncated death domain; TNF receptor superfamily member 10d; TNF receptor-related receptor for TRAIL; TNF-related apoptosis-inducing ligand receptor 4; TNFRSF10D; TR10D; TRAIL receptor 4; TRAIL receptor with a truncated death domain; TRAIL-R4; TRAILR4; TRUNDD; Tumor necrosis factor receptor superfamily member 10D; tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
Limited Uses
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