DDX39A (F7T4J) Rabbit mAb #47857
- WB
- IP
Supporting Data
REACTIVITY | H M R Mk |
SENSITIVITY | Endogenous |
MW (kDa) | 49 |
Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
Application | Dilution |
---|---|
Western Blotting | 1:1000 |
Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
DDX39, also known as DDX39A, is a DEAD-box helicase highly homologous to UAP56 and is upregulated in lung squamous cell cancers (9,10). DDX39 has been shown to bind to TRF2 to regulate telomere protection (11). Furthermore, DDX39 is overexpressed in several cancer types, which is associated with poor prognosis (12-15). Both UAP56 and DDX39 are hijacked by various viral replication machineries to enable viral reproduction and mRNA export (16-18). UAP56 and DDX39 have also been implicated in promoting the AR-V7 splice variant in advanced prostate cancers (19).
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- Fleckner, J. et al. (1997) Genes Dev 11, 1864-72.
- Strässer, K. et al. (2002) Nature 417, 304-8.
- Custódio, N. et al. (2004) RNA 10, 622-33.
- Kapadia, F. et al. (2006) Gene 384, 37-44.
- Shen, J. et al. (2007) J Biol Chem 282, 22544-50.
- Kota, K.P. et al. (2008) J Cell Sci 121, 1526-37.
- Majerciak, V. et al. (2010) Virology 407, 206-12.
- Sugiura, T. et al. (2007) Exp Cell Res 313, 782-90.
- Sugiura, T. et al. (2007) Cancer Biol Ther 6, 957-64.
- Yoo, H.H. and Chung, I.K. (2011) Aging Cell 10, 557-71.
- Kikuta, K. et al. (2012) J Proteomics 75, 1089-98.
- Kuramitsu, Y. et al. (2013) Anticancer Res 33, 2557-60.
- Kuramitsu, Y. et al. (2013) Anticancer Res 33, 3133-6.
- Xing, C. et al. (2020) Front Oncol 10, 1261.
- Dufu, K. et al. (2010) Genes Dev 24, 2043-53.
- Zielke, B. et al. (2011) J Virol 85, 1804-19.
- Wisskirchen, C. et al. (2011) J Virol 85, 8646-55.
- Nakata, D. et al. (2017) Biochem Biophys Res Commun 483, 271-276.
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