Render Target: STATIC
Render Timestamp: 2024-10-09T09:44:09.385Z
Commit: f04ddd7fea9fb3592f59f61482fcb94610d25cbe
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

DELE1 (E9K6O) Rabbit mAb #98271

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Transfected Only
    MW (kDa) 60
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    DELE1 (E9K6O) Rabbit mAb recognizes overexpressed levels of total DELE1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human DELE1 protein.

    Background

    DAP3-binding cell death enhancer 1 (DELE1) is a protein kinase activator that responds to mitochondrial stress as part of the integrated stress response (ISR) (1-4). The OMA1-DELE1-HRI ISR pathway is activated by cellular stressors such as iron deficiency, causing OMA1 to cleave DELE1 into a short form (DELE1(S) or S-DELE1), which accumulates in the cytosol and activates the protein kinase activity of EIF2AK1/HRI (1-4). Under stable cell conditions, DELE1 is quickly degraded (4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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