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REACTIVITY SENSITIVITY MW (kDa) SOURCE
78 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Etk/BMX Antibody recognizes endogenous levels of total Etk (BMX) protein.


Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human Etk (BMX) protein. Antibodies are purified by protein A and peptide affinity chromatography.

Etk, also known as BMX, is a member of the Bruton's tyrosine kinase (Btk) family (1). It is expressed in a variety of hematopoietic, epithelial and endothelial cells. Etk, like other Btk family members, contains a pleckstrin homology (PH) domain and Src homology SH3 and SH2 domains. It participates in multiple signal transduction pathways (2). Phosphorylation of Tyr566 by Src kinase is required for activation of Etk in vivo (3). In endothelial and epithelial cells, Etk is regulated by FAK through phosphorylation at Tyr40 (4).


1.  Tamagnone, L. et al. (1994) Oncogene 9, 3683-8.

2.  Qiu, Y. and Kung, H.J. (2000) Oncogene 19, 5651-61.

3.  Tsai, Y.T. et al. (2000) Mol Cell Biol 20, 2043-54.

4.  Chen, R. et al. (2001) Nat Cell Biol 3, 439-44.


Entrez-Gene Id 660
Swiss-Prot Acc. P51813


For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
Tween is a registered trademark of ICI Americas, Inc.

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Etk/BMX Antibody