FABP4 (D25B3) XP^® Rabbit mAb #3544

Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

FABP4 (D25B3) XP^® Rabbit mAb detects endogenous levels of total FABP4 protein. This antibody may cross react with other FABP family members.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence of human FABP4.

Background

Fatty acid binding proteins (FABPs) bind to fatty acids and other lipids to function as cytoplasmic lipid chaperones (1). They participate in the transport of fatty acids and other lipids to various cellular pathways (2). The predominant fatty acid binding protein found in adipocytes is FABP4, also called adipocyte fatty acid binding protein or aP2. FABP4 is also expressed in macrophages (3). FABP4 knockout mice fed a high-fat and high-calorie diet become obese but develop neither insulin resistance nor diabetes, suggesting that this protein might be a link between obesity and insulin resistance and diabetes (4). Mice deficient in both FABP4 and ApoE show protection against atherosclerosis when compared with mice deficient only in ApoE (3). Mice carrying a FABP4 genetic variant exhibit both reduced FABP4 expression and a reduced potential for developing type 2 diabetes and coronary heart disease. A related study in humans indicated a similar pattern, suggesting that FABP4 may be a potential therapeutic target in the treatment of these disorders (1).

1. Tuncman, G. et al. (2006) Proc Natl Acad Sci U S A 103, 6970-5.
2. Haunerland, N.H. and Spener, F. (2004) Prog Lipid Res 43, 328-49.
3. Makowski, L. et al. (2001) Nat. Med. 7, 699-705.
4. Hotamisligil, G.S. et al. (1996) Science 274, 1377-1379.

Pathways & Proteins

Explore pathways + proteins related to this product.

Select Your Pathway/Protein Protein: P15090

Database Links

Swiss-Prot Acc.: P15090

Entrez-Gene Id: 2167

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