FABP5 (D1A7T) Rabbit mAb #39926
- WB
- IHC
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 15 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunohistochemistry (Paraffin) | 1:1200 |
Storage
Protocol
Specificity / Sensitivity
FABP5 (D1A7T) Rabbit mAb recognizes endogenous levels of total FABP5 protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human FABP5 protein.
Background
Fatty acid binding proteins (FABPs) bind to fatty acids and other lipids to function as cytoplasmic lipid chaperones (1). They participate in the transport of fatty acids and other lipids to various cellular pathways (1). They are critical mediators of metabolic processes, and are increasingly being understood to play key roles in disease (2). FABP5 is known as the epidermal fatty acid binding protein as it was originally identified in studies on psoriasis (3) where it was shown to play a role a role in keratinocyte differentiation (4). It has since been found to play diverse roles in other normal physiological processes as well as in disease states (5).
- Haunerland, N.H. and Spener, F. (2004) Prog Lipid Res 43, 328-49.
- Hotamisligil, G.S. and Bernlohr, D.A. (2015) Nat Rev Endocrinol 11, 592-605.
- Madsen, P. et al. (1992) J Invest Dermatol 99, 299-305.
- Siegenthaler, G. et al. (1994) Biochem J 302 ( Pt 2), 363-71.
- Thumser, A.E. et al. (2014) Curr Opin Clin Nutr Metab Care 17, 124-9.
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