Factor XIIIA (E980.1) Mouse mAb #84321
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Mouse IgG1 |
Application Key:
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| IHC Leica Bond | 1:50 - 1:200 |
| Immunohistochemistry (Paraffin) | 1:100 - 1:400 |
Storage
Protocol
Specificity / Sensitivity
Factor XIIIA (E980.1) Mouse mAb recognizes endogenous levels of Factor XIIIA protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a prokaryotic recombinant protein corresponding to a portion of the C-terminus of the blood coagulation factor XIIIa protein.
Background
Factor XIIIA, or fibrin stabilizing factor, is activated by thrombin and Ca2+ to a protransglutaminase in the final step of the blood coagulation cascade that cross-links fibrin chains (1). This enzyme catalyzes the gamma-glutamyl-epsilon-lysine cross-linking between fibrin molecules, stabilizing the fibrin clot (1,2). It is widely expressed in dermal dendritic cells (3). High expression of Factor XIIIA positive cells can be indicative of inflammatory conditions such as lichen planus and psoriasis (4).
Limited Uses
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