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FATP4/SLC27A4 (F4Y5M) Rabbit Monoclonal Antibody #35214

Filter:
  • WB

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 70
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Simple Western™ 1:10 - 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    FATP4/SLC27A4 (F4Y5M) Rabbit Monoclonal Antibody recognizes endogenous levels of total FATP4/SLC27A4 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human FATP4/SLC27A4 protein.

    Background

    Long-chain fatty acid transport protein 4 (FATP4), also known as solute carrier family 27 member 4 (SLC27A4), is a transmembrane protein in the endoplasmic reticulum (ER) (1). It is an acyl-CoA synthetase and has higher enzymatic activity toward saturated and monounsaturated very long-chain fatty acids (1,2). Studies show that FATP4/SLC27A4 promotes fatty acid uptake by endothelial cells through its acyl-CoA synthetase activity. This enzymatic activity requires ATP produced in mitochondria that are positioned closely to the ER (3). In addition, during starvation of myoblasts, perilipin-5 on lipid droplets interacts with FATP4/SLC27A4 on mitochondria to promote fatty acid transport from lipid droplets to mitochondria (4).

    Alternate Names

    ACSVL4; Arachidonate--CoA ligase; FATP-4; FATP4; Fatty acid transport protein 4; IPS; Long-chain fatty acid transport protein 4; Long-chain-fatty-acid--CoA ligase; S27A4; SLC27A4; solute carrier family 27 (fatty acid transporter), member 4; Solute carrier family 27 member 4; Very long-chain acyl-CoA synthetase 4

    For Research Use Only. Not for Use in Diagnostic Procedures.
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