FATP4/SLC27A4 (F4Y5M) Rabbit mAb #35214

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Supporting Data

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	70
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Simple Western™	1:10 - 1:50

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

FATP4/SLC27A4 (F4Y5M) Rabbit mAb recognizes endogenous levels of total FATP4/SLC27A4 protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human FATP4/SLC27A4 protein.

Background

Long-chain fatty acid transport protein 4 (FATP4), also known as solute carrier family 27 member 4 (SLC27A4), is a transmembrane protein in the endoplasmic reticulum (ER) (1). It is an acyl-CoA synthetase and has higher enzymatic activity toward saturated and monounsaturated very long-chain fatty acids (1,2). Studies show that FATP4/SLC27A4 promotes fatty acid uptake by endothelial cells through its acyl-CoA synthetase activity. This enzymatic activity requires ATP produced in mitochondria that are positioned closely to the ER (3). In addition, during starvation of myoblasts, perilipin-5 on lipid droplets interacts with FATP4/SLC27A4 on mitochondria to promote fatty acid transport from lipid droplets to mitochondria (4).

Database Links

UniProt ID: Q6P1M0

Entrez-Gene Id: 10999

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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