FBXO7 (D8L4E) Rabbit mAb #57981
- WB
Supporting Data
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 65-72 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
FBXO7 (D8L4E) Rabbit mAb recognizes endogenous levels of total FBXO7 protein. FBXO7 (D8L4E) Rabbit mAb detects two bands bands in human cerebellum, consistent with multiple FBXO7 isoforms generated by alternative splicing.
Species Reactivity:
Human, Mouse
Source / Purification
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the N-terminus of human FBXO7 protein.
Background
F-box only protein 7 (FBXO7) is the substrate recognition component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. This complex mediates ubiquitination and degradation of targeted proteins. Several “PARK” chromosomal loci have been associated with monogeneic forms of PD, including PARK15 (1). The associated allele for PARK15 is FBXO7, which encodes the FBXO7 protein. Mutations in FBXO7 cause early-onset autosomal recessive PD, and alterations in FBXO7 normal function, e.g. the protein degradation process, may contribute to PD etiology (2, 3). Additionally, expression of specific FBXO7 isoforms generated by alternative splicing is linked with PD (4).
Limited Uses
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