FcεRIA (E6D9L) Rabbit mAb #16992
- WB
Supporting Data
| REACTIVITY | M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 45-65 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
FcεRIA (E6D9L) Rabbit mAb recognizes endogenous levels of total FcεRIA protein.
Species Reactivity:
Mouse
Source / Purification
Monoclonal antibody is produced by immunizing animals with mouse FcεRIA recombinant protein.
Background
FcεRI, the high affinity IgE receptor complex, is made up of an α-chain, a β-chain, and a homodimer of two disulphide-linked γ-chains (1-4). It is expressed by mast cells, basophils, and antigen-presenting cells (1-4). The α-chain, FcεRIA, binds the Fc portion of IgE, which initiates antigenic crosslinking and leads to an allergic response, resulting in secretion of molecules such as interleukin-4 (IL-4), interleukin-6 (IL-6), tumor-necrosis factor-α (TNF-α), and granulocyte-macrophage colony-stimulating factor (GM-CSF) (1-5).
Limited Uses
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