Render Target: STATIC
Render Timestamp: 2024-12-13T12:15:52.276Z
Commit: 611277b6de3cd1bb065350b6ef8d63df412b7185
XML generation date: 2024-09-30 01:59:54.098
Product last modified at: 2024-11-26T13:00:19.928Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

FRS2-α (E4B4T) Rabbit mAb #94826

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 78, 80, 85
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    FRS2-α (E4B4T) Rabbit mAb recognizes endogenous levels of total FRS2-α protein. This antibody detects a band of unknown origin at 60 kDa.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly149 of human FRS2-α protein.

    Background

    Fibroblast growth factor receptor substrate 2 (FRS2, also called Suc-associated neurotrophic factor-induced tyrosine-phosphorylated target or SNT) participates in the transmission of extracellular signals from the fibroblast growth factor receptor (FGFR). FGFR activation leads to tyrosine phosphorylation of FRS2 (1). Two FRS2 family members have been identified, FRS2-α (SNT1) and FRS2-β (SNT2) (2), which are phosphorylated by these receptor tyrosine kinases (RTKs). Once phosphorylated, they recruit SH2 domain-containing proteins, including Grb2 and SHP-2 (3,4), mediating downstream signaling. Tyr436 is required for efficient SHP-2 recruitment (5), whereas Tyr196 functions as a docking site for Grb2-Sos complexes (6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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