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GLIPR2 (F7H7V) Rabbit Monoclonal Antibody #86955

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  • WB
  • IHC

    Product Specifications

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 17
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunohistochemistry (Paraffin) 1:100 - 1:400

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    GLIPR2 (F7H7V) Rabbit Monoclonal Antibody recognizes endogenous levels of total GLIPR2 protein. An unknown background band is detected at 65 kDa in some human and mouse cell lines.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro135 of human GLIPR2 protein.

    Background

    Glioma pathogenesis-related protein 2 (GLIPR2), also known as Golgi-associated PR-1 protein (GAPR-1), is a Golgi-associated protein belonging to the PR-1 protein family (1). GLIPR2 contains a sperm-coating protein (SCP) domain, also known as a CAP domain; however, in contrast to other SCP domain-containing proteins, it does not have a signal peptide and is not secreted via the classical secretory pathway (2). GLIPR2 is expressed in monocytes, macrophages, natural killer (NK) cells, and T cell subsets (3). GLIPR2 binds Beclin-1 and is a negative regulator of autophagy that inhibits PtdIns3K-C1 complex activity (4,5). GLIPR2 promotes epithelial to mesenchymal transition in vitro, and is expressed at high levels in fibrotic kidney (6). GLIPR2 has been identified as a marker for type 1 migratory dendritic cells (DC1s) (7) and a potential biomarker and tumor suppressor in a pan-cancer analysis (3).

    Alternate Names

    17kD fetal brain protein; C9orf19; GAPR-1; GAPR1; GLI pathogenesis related 2; GLI pathogenesis-related 2; Glioma pathogenesis-related protein 2; GliPR 2; GLIPR2; Golgi-associated plant pathogenesis-related protein 1; Golgi-associated PR-1 protein

    For Research Use Only. Not for Use in Diagnostic Procedures.
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