Glut4 Antibody

Inquiry Info. # 2299

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Product Specifications

REACTIVITY
SENSITIVITY	Endogenous
MW (kDa)	45
SOURCE	Rabbit

Product Information

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Glut4 Antibody detects endogenous levels of total Glut4 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to a sequence of human Glut4 (around Q6). Antibodies are purified by protein A and peptide affinity chromatography.

Background

A group of related glucose transporters (Glut1-5 and 7) mediate the facilitated diffusion of glucose in nonepithelial mammalian tissues. Within insulin-responsive tissues such as muscle and fat, Glut1 contributes to basal glucose uptake while Glut4 is responsible for insulin-stimulated glucose transport (1-3). Glut4 is a 12-transmembrane domain protein that facilitates glucose transport in the direction of the glucose gradient. This transporter localizes to intracellular organelles (endosomes) in unstimulated cells and translocates to the cell surface following insulin stimulation (1,2,4). Translocation of Glut4 is dependent on Akt, which may act by phosphorylating AS160, a RabGAP protein involved in membrane trafficking (5).

Alternate Names

Glucose transporter type 4, insulin-responsive; GLUT-4; GLUT4; GTR4; insulin-responsive glucose transporter type 4; SLC2A4; solute carrier family 2 (facilitated glucose transporter), member 4; solute carrier family 2 member 4; Solute carrier family 2, facilitated glucose transporter member 4

Database Links

UniProt ID: P14672

Entrez-Gene Id: 6517

Limited Uses

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For Research Use Only. Not for Use in Diagnostic Procedures.

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Glut4 Antibody #2299